TY  - JOUR
TI  - Impact of ceftazidime/avibactam combined dynamic nutritional support on intestinal barrier function in sepsis patients: A focus on barrier protection mechanisms
AU  - Sha, Xiaojuan
AU  - Sun, Lijuan
AU  - Wu, Jun
JO  - Pakistan Journal of Pharmaceutical Sciences
VL  - 39
IS  - 6
SP  - 1618
EP  - 1624
PY  - 2026
DA  - 2026/06
KW  - Avibactam
KW  - Ceftazidime
KW  - Intestinal barrier dysfunction
KW  - Inflammatory cytokines
KW  - Sepsis
DO  - 10.36721/PJPS.2026.39.6.153.1
AB  - Background: Studies have confirmed that the progression of sepsis is closely related to intestinal barrier dysfunction, including intestinal mucosa ischemia and hypoxia, flora imbalance and epithelial cell apoptosis. Therefore, protecting the intestinal barrier function has become a key link in the comprehensive treatment of sepsis. Objectives: This study evaluated the impact of a novel β-lactamase inhibitor compound preparation (ceftazidime/avibactam) on intestinal barrier function in sepsis patients. Methods: The study included 108 sepsis patients (January 2022–August 2025) and grouped them as an observation group (54 cases, ceftazidime/avibactam + dynamic nutritional support) and a control group (54 cases, ceftazidime/sulbactam + dynamic nutritional support). Of the outcome measures assessed, the 28-day all-cause mortality was primary, while ICU length of stay, mechanical ventilation time, antibiotic course, intestinal barrier function markers (DAO, LBP, Claudin-1) and inflammatory cytokines (IL-6, TNF-α) were secondary. Results: The results indicated lower 28-day all-cause mortality in the observation group compared with the control group, along with shorter ICU length of stay, mechanical ventilation time and time to negative blood culture conversion (P < 0.05). Regarding post-treatment intestinal barrier function, DAO, LBP and FC were lower while claudin-1 was higher in the observation group compared to the control group (P < 0.05). Analysis of inflammatory factors also showed greater reductions in IL-1β, IL-6 and TNF-α in the observation group post-treatment (P < 0.05). Conclusion: Ceftazidime/Avibactam plus dynamic nutritional support improves intestinal barrier function in sepsis patients and alleviates inflammatory reactions, thereby enhancing patient survival safety.
ER  -