Pakistan Journal of Pharmaceutical Sciences

Abstract: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide, with no cure at present. Vitamin D (VD) is a fat-soluble vitamin, which has been recognized as one of the major influencing factors of T2DM. However, the specific relationship between T2DM and VD remains elusive. In this study, we analyzed the correlation of VD with glucose-lipid metabolism and nutritional status in patients with newly diagnosed T2DM, so as to understand the role of VD in T2DM more comprehensively. First, we compared the differences in VD (vitamin D3), glucose-lipid metabolism and nutrient proteins between patients with T2DM and the healthy population and our patients with T2DM had lower VD and nutrient proteins and higher glucose and lipids (P<0.05). By receiver operating characteristic (ROC) curve analysis, it was seen that VD demonstrated an excellent assessment of the occurrence of T2DM as well as prognostic progression. In addition, we found that VD was negatively correlated with fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), triglyceride (TG) and total cholesterol (TC) in patients with T2DM (P<0.05), whereas it was negatively correlated with nutrient protein were all positively correlated (P<0.05). These results suggest that we can monitor the VD levels of T2DM patients in future clinical practice to assess their pathologic progression, so as to intervene in a timely manner to ensure the health of the patients.