Effect of thrombolytic therapy with rt-PA at different times on neurological function and complications in patients with acute cerebral infarction

This study investigates the effects of rt-PA thrombolytic therapy at varying times on neurological function and complications in acute cerebral infarction (ACI) patients. A total of 120 ACI patients admitted between August 2019 and July 2021 were divided into three groups based on the timing of rt-PA treatment: 4.5h (25 patients). All received standard treatment and rt-PA IV thrombolysis. Key comparisons included cerebral oxygen metabolism, oxidative stress, neural markers, hemodynamics, coagulation function, NIHSS scores, ADL, clinical efficacy, and complications. Results showed that 48 hours post-treatment, SjvO2 levels were significantly higher in the 4.5h group. SOD levels were also higher in the earlier groups, while MDA levels were lower. Three months after treatment, NIHSS scores were significantly lower and ADL scores higher in the <3h and 3-4.5h groups, with lower complication rates. Efficacy was similar within 3 hours and 3–4.5 hours, but complications increased significantly after 4.5 hours.