By: Yun-Kui Huo, Xiu-Wen Yan, Ru-Xiong Bai, Fu Liu
Keywords: Esophageal carcinoma; programmed death ligand 1; insulin-like growth factor-binding protein-2; prognosis.
DOI : 10.36721/PJPS.2024.37.6.REG.1315-1321.1
Abstract: This study investigates the prognostic value of serum biomarkers PD-L1 and IGFBP-2 in patients with esophageal carcinoma. It finds a significant positive correlation between these biomarkers and established tumor markers CEA and CYFRA21-1. The 3-year survival rate for the patient cohort was 45.10%, with deceased patients showing significantly higher levels of PD-L1 and IGFBP-2. ROC analysis indicates a strong predictive value for these biomarkers, with combined use potentially enhancing diagnostic accuracy. Kaplan-Meier curves reveal lower survival rates for patients with high biomarker expression. The study suggests that PD-L1 and IGFBP-2 could be valuable for clinical management and prognostic evaluation of esophageal carcinoma patients.
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