Pakistan Journal of Pharmaceutical Sciences

Abstract: Chronic obstructive pulmonary disease (COPD), currently one of the most common chronic lung diseases in clinical practice, is the third leading cause of death globally, after ischemic heart disease and stroke. In this study, we analyzed the factors related to malnutrition in chronic obstructive pulmonary disease and found that long-term smoking, body mass index, fasting plasma glucose, and total cholesterol were all independent risk factors. This suggests that in future clinical treatment of chronic obstructive pulmonary disease, attention should be paid to these indicators to prevent malnutrition (P<0.05). Ajuga ciliata Bunge is one of the drugs commonly used in traditional Chinese medicine for the adjuvant treatment of lung inflammation and sore throat. We found that the addition of Ajuga ciliata Bunge to the treatment of COPD can effectively improve the inflammatory response of patients. Meanwhile, the improvement of inflammatory response was more significant in COPD patients who were malnourished among them (P<0.05). In addition, the incidence of adverse reactions with Ajuga ciliata Bunge was low and improved the patients' treatment satisfaction. These results suggest that Ajuga ciliata Bunge has an important application in the treatment of COPD in the future.