By: Si-Cheng Zhao, Dan Wang, Ting-Yan Wu, Ming-Jing Fu, Xiao-Ming Lu
Keywords: Rosacea; Compound glycyrrhizin; fractional CO2 laser; skin barrier function
DOI : 10.36721/PJPS.2025.38.2.REG.13259.1
Abstract: Rosacea is a chronic facial inflammatory disease affecting quality of life, with complex causes including psychological, lifestyle and immune factors. This study examines the use of compound glycyrrhizin with fractional CO2 laser treatment for rosacea patients. From January 2018 to January 2022, 108 patients with rosacea lesions were randomly assigned to a control group (conventional treatment) and an observation group (glycyrrhizin plus laser treatment). Both groups received 12 weeks of therapy. Analysis using SPSS26.0 and GraphPad Prism 8.0 showed improvement in skin lesions and barrier function post-treatment. The observation group had fewer lesions and better skin hydration compared to the control group (P<0.05). Adverse reactions were higher in the observation group but not significantly different (P>0.05). The combination treatment enhances therapeutic effects, improves skin lesions, and strengthens the skin barrier, warranting promotion.
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