Effect of pitavastatin in different SLCO1B1 backgrounds on repaglinide pharmacokinetics and pharmacodynamics Page No: 577-584

By: Jie Zhu, Min Song, Hong-Yi Tan, Li-Hua Huang, Zhi-Jun Huang, Chang Liu, Zhi-Min Fu, Yuan-Yuan Huang, Zhi-Rong Tan, Xiao-Ping Chen, Hong Yuan, Guo-Ping Yang

Abstract: The effect of pitavastatin and SLCO1B1 genetic background on the pharmacokinetic and pharmacodynamic properties of repaglinide was investigated. In this randomized, placebo-controlled, crossover study, twelve healthy Chinese males were administered with pitavastatin 4 mg/d or the placebo for 5 d followed by repaglinide 4 mg given orally on d 5



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