Formulation, evaluation and optimization of the felodipine nanosuspension to be used for direct compression to tablet for in vitro dissolution enhancement Page No: 1927-1936

By: Dhaval Mori, Jalpa Makwana, Ramesh Parmar, Kalpesh Patel, Jayant Chavda

Keywords: High speed homogenization, media milling, simplex lattice design, saturation solubility, process parameter optimization.

Abstract: The oral bioavailability of felodipine very low, nearly just 151ue to its limited solubility and high first pass metabolism.



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