Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity Page No: 2585-2597

By: Majid Nazir, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, M Shahid, H Fatima, Sunniya Iftikhar, Rahman Shah Zaib Saleem

Keywords: 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-yl hydro sulfide; alkyl/aralkyl halides; bacterial biofilm inhibition; antibacterial; anticancer; cytotoxicity.

DOI : doi.org/10.36721/PJPS.2019.32.6.REG.2585-2597.1

Abstract: In the study presented here, the nucleophilic substitution reaction of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide was carried out with different alkyl/aralkyl halides (5a-r) to form its different S-substituted derivatives (6a-r), as depicted in scheme 1



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