By: Lan Liu, Jinyang Zhang, Baocai Li, Mi Zhang
Keywords: Austroyunnane B, anti-inflammation, RAW264.7 cells, sesquiterpenoid
DOI : doi.org/10.36721/PJPS.2020.33.1.REG.215-219.1
Abstract: Austroyunnane B, a highly oxidized guaianolide-type sesquiterpenoid isolated from the whole plants of Artemisia austro-yunnanensis by our group, revealed significant inhibition against NO production on the model of lipopolysaccharide (LPS)-stimulated RAW264.7 cells. In this study, its anti-inflammatory effect on some inflammatory cytokines and proteins was further evaluated using the same model. As results, co-treatment with different concentrations (0.39-100?mol /L) of austroyunnane B on LPS-induced RAW264.7 cells displayed reduction of the nitric oxide (NO) generation in a dose dependent manner. It also showed a concentration-dependent inhibition against TNF-?, IL-1?, IL-6 and IL-10, and down-regulation of protein expressions of iNOS and COX-2 on that model at the range of 0.625-10?mol/L, suggesting that austroyunnane B can be used as a lead compound for the development of inflammatory drug.
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