Pakistan Journal of Pharmaceutical Sciences

Abstract: Meningitis is a neurological condition that can be severe causing epilepsy. This study analyzed the efficacy of Xiao Chai Hu Tang plus minus Tang combined with sodium valproate in the treatment of meningitis-associated epilepsy. 100 patients with meningitis-associated epilepsy during June 2022 to June 2024 were randomised to control group (n=50) and study group (n=50). Both groups were treated with sodium valproate and study group was added Xiao Chai Hu Tang plus minus Tang treatment. To evaluate the traditional Chinese medicine symptom (TCMS) scores, cerebrospinal fluid returning to normal proportion, neurological factors, inflammatory factors, immune indicators, life qualities scores, functional area scores, clinical efficacy and adverse reactions incidence in both groups. All the results of the both groups post-therapy were better versus pre-therapy. Post-therapy, the TCMS scores, erebrospinal fluid returning to normal proportion, neurological factors, immune indicators, life qualities scores, functional area scores and clinical efficacy were above to control group, the inflammatory factors and adverse reactions incidence were below in study group (p<0.05). The efficacy of this combination therapy for the treatment of meningitis-associated epilepsy is accurate and has high clinical value.