Pakistan Journal of Pharmaceutical Sciences

Abstract: The development of colorectal carcinoma, a prevalent malignancy, remains insufficiently understood. This study examined the role of LINC01106 in colorectal carcinoma progression and elucidated the underlying molecular mechanisms. The expression of LINC01106 was analyzed using data from the database of gene expression profiling interactive analysis and 50 clinical specimens. The prognostic relevance of LINC01106 in colorectal carcinoma was assessed. Functional assays were performed after LINC01106 knockdown to assess changes in proliferation and metastatic capabilities. The expression of LINC01106 was found to be significantly elevated in colorectal carcinoma tissues and was linked to unfavorable overall survival outcomes in patients with colorectal carcinoma. Knockdown of LINC01106 significantly suppressed the proliferation and metastasis of colorectal carcinoma cells. MiR-744-5p was identified as a direct target of LINC01106, exhibiting an inverse correlation with LINC01106 expression. Elevated expression of miR-744-5p hindered the proliferation and metastatic potential of colorectal carcinoma cells—effects that were reversed by co-overexpression of LINC01106. In summary, LINC01106 was highly expressed in colorectal carcinoma and enhanced the proliferation and metastasis of colorectal carcinoma cells by directly interacting with miR-744-5p, highlighting its potential as a therapeutic target.