Pakistan Journal of Pharmaceutical Sciences

Abstract: This quantitative research assesses the effectiveness of enteral nutrition guidance on the immune function of subjects with acute renal failure undergoing continuous renal replacement therapy, with either furosemide or sodium bicarbonate interventions. The findings revealed that both interventions indeed enhanced the renal, metabolic, nutritional and immune profiles of the patients over 14 days, which were not different from each other. Sodium bicarbonate had a numerically superior effect in correcting acidosis, which was marginally superior to placebo, whereas furosemide significantly improved the fluid clearance. Regression analysis on the chosen variables showed that serum creatinine, BUN, pH, BMI and NLR were significant for outcomes. Most prominently, changes in the nitrogen balance and oxidative stress indicators were differentiated and significantly better in both groups due to the structured EN approach. These outcomes underscore more importance of providing personalized medical care in the care of critical illness and interactively integrating EN with pharmacologic approaches to promote the recovery as well as the immune status of the patients.