By: Sijun Ruan, Xiqing Cheng
Keywords: Knee osteoarthritis; hyaluronic acid; non-steroidal anti-inflammatory drugs; pain; inflammatory factors
DOI : 10.36721/PJPS.2025.38.5.REG.13889.1
Abstract: Knee osteoarthritis (KOA) is a chronic disease with limited clinical treatment and easy recurrence. This study analyze the effectiveness of intra-articular hyaluronic acid (HA) injection combined with oral nonsteroidal anti-inflammatory drugs (NSAID) in treating KOA, providing scientific basis for improving the therapeutic effect of this disease. 100 KOA patients admitted to our hospital from December 2021 to December 2023 were divided into control group (n=50) and study group (n=50). Both groups were treated with oral NSAID, study group were added with intra-articular HA injections. The pain scores (VAS), knee osteoarthritis indicator score (WOMAC), knee osteoarthritis outcome score (KOOS), Lysholm score, knee joint range of motion, inflammatory indicators, clinical efficacy and adverse reactions were compared among both groups. After treatment, all indicators in both groups remarkably improved (P<0.05). The KOOS score, Lysholm score, knee mobility and clinical efficacy in study group were remarkably higher than control group, and VAS score, WOMAC score and inflammatory factor level were less than control group (P<0.05). No significant discrepancies in the adverse reactions among both groups (P>0.05). The efficacy of the combined treatment is remarkable without increased adverse reactions and deserves to further popularize its use in the clinic.
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