Pakistan Journal of Pharmaceutical Sciences

Abstract: This research which was conducted at Shandong Provincial Third Hospital in Jinan City, China, evaluated the effects of hypotension on the electroencephalogram (EEG) subsequent to dexmedetomidine induction in patients having orthopedics. 120 patients were used to capture EEG, hemodynamic and respiratory data which makes and provides an enhanced and complete picture of physiological changes during controlled hypotension. Study outcomes pointed to a highly frequent mild-moderate hypotension: The EEG/Paed patients with predictors of a mean arterial pressure (MAP) reduction demonstrated significantly lower heart rate at baseline, enhanced delta+theta activity and higher depth of sedation. Measures like administration of fluids and use of vasopressors were for hypotensive episodes and they responded well within few minutes. The findings show the necessity of efficient procedures for controlling anesthesia for the improvement of effectiveness, safety and risk reduction during surgery. Specifically in the department of anesthesiology. The study effectively links EEG changes to hypotension during dexmedetomidine anesthesia, highlighting EEG’s predictive value and real-time utility in guiding interventions to enhance patient safety and hemodynamic stability. The study effectively correlates EEG markers with hypotension, offering actionable thresholds for anesthesiologists. Early detection of delta/theta activity alongside MAP reductions enhances proactive management, improving patient safety during high-risk surgeries.