By: Kuanyu Nian, Dan Zhang
Keywords: Elderly patients; Gut microbiota diversity; Non-erosive gastroesophageal reflux disease; Proton pump inhibitors; Quality of life
DOI : 10.36721/PJPS.2025.38.6.REG.13939.1
Abstract: This study investigated the effects of Proton pump inhibitors (PPIs) combined with triple therapy on elderly non-erosive gastroesophageal reflux disease (NERD) patients. A total of 120 elderly patients diagnosed with NERD were divided into two groups: the study group received PPIs combined with triple therapy, while the control group received PPI monotherapy. Significant improvements were observed in the study group compared with the control group: gut microbiota diversity (Shannon Index: from 3.80±0.40 to 5.30±0.60), increased abundance of beneficial Lactobacillus and Bifidobacterium and reduced Enterococcus levels (All p<0.001). Visceral hypersensitivity scores showed increased pressure and pain thresholds (p<0.001) and reduced urgency and bloating (p<0.05). Gastrointestinal hormone such as motilin, ghrelin levels were increased (both p<0.001), and somatostatin was decreased (p=0.034). Systemic inflammatory markers such as IL-6, CRP, TNF-?, and IL-1? significantly declined, while anti-inflammatory IL-10 increased (All p<0.001). GERDQ scores improved more significantly in the study group (p?
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