Pakistan Journal of Pharmaceutical Sciences

Abstract: This study constructed a chain analysis model linking pharmaceutical attributes, physician preferences, clinical efficacy and pharmacoeconomic outcomes. Using multicenter prospective data, we analyzed the multi-level mechanisms influencing the key pharmaceutical attributes of emergency trauma hemostatics. A total of 1,500 patients from six hospitals in China were included. The pharmacological properties of tranexamic acid, ethamide and hemocoagulase were analyzed and their impact on physician preferences, efficacy and economic outcomes was assessed. Results showed that antifibrinolytic mechanism (weighted 38.2%), onset of action (29.7%) and thrombotic risk (24.1%) were the core attributes influencing physician preferences. Due to its advantageous pharmaceutical attributes, tranexamic acid had the shortest hemostatic time (14.5 ± 3.0 minutes), the lowest 24-hour blood transfusion volume (320 ± 70 ml) and the best cost-effectiveness (328.6 yuan/minute). This study provides evidence-based guidance for the precise selection of hemostatics based on pharmaceutical attributes.