Pakistan Journal of Pharmaceutical Sciences

Abstract: Background: Degenerative diseases of the spine seriously affect the quality of life of patients and clinical treatment is currently facing certain challenges. Objectives: To analyze the clinical efficacy of sodium heptasaponin combined with diosmin in postoperative patients undergoing posterior open surgery for degenerative diseases of the spine (POSDDS). Methods: 160 patients with POSDDS from Zhoushan Guanghua Hospital between January 2024 and December 2024 were categorised into SA and SD groups, both groups were treated with sodium heptasaponin and the SD group was added with diosmin. The primary assessment was inflammatory indexes, immune indexes [immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM)], spinal function score (JOA), pain score (VAS) and clinical efficacy in both groups. Secondary outcomes included quality of life [(SF-36) score], complication and adverse reactions incidences. Results: After treatment, the indicators of both groups were remarkably difference with pre-treatment (P<0.05). The immune indicators, JOA score, clinical efficacy and SF-36 score in the SD group were significantly higher than SA group and inflammatory indicators, VAS score and the incidence of complications and adverse reactions were significantly lower than SA group (P<0.05). Conclusion: Sodium heptasaponin combined with diosmin can effectively optimize the inflammatory and immune indexes of POSDDS patients, elevate spinal function and quality of life, and reduce adverse events, thus deserving clinical promotion.