Pakistan Journal of Pharmaceutical Sciences

Abstract: Background: People who experience various traumas often develop peripheral nerve injuries (PNIs). Currently available strategies are insufficient to fully recover nerve damage. Plants are used to treat a variety of illnesses. Objectives: In this study, we investigated the possible effect of Betula utilis on the restoration of muscle function following an injury to a peripheral nerve. Methods: Here, we treated PNI by using bark extract from Betula utilis. First, 32 healthy albino mice were equally divided into 4 groups. Bark extract (orally) at varying concentrations (25, 50, 100, and 200 mg/kg) was assessed for two weeks. Behavioral assessment and histology of vital organs were performed for the dose adjustment. Afterwards, for sciatic nerve injury, 32 mice were equally divided into four groups: Control and sham (groups 1 and 2, treated with normal saline) and treatment groups (groups 3 and 4, B. utilis extract, 25 and 50mg/kg). Behavioral analyses assess sensorimotor recovery. All observations were analyzed statistically at a p-value of p<0.05. Results: Behavioral analyses depict an improvement (statistically significant) in the treated group as compared to the non-treated group. Serum samples analysed for oxidative stress markers showed statistically significant (p<0.05) results for TAC (Total antioxidant capacity) and TOC (Total oxidative stress) in the treated groups. Conclusion: In summary, B. utilis extract improved sensorimotor function restoration, and to determine its appropriateness for people, more research is necessary.