By: Anosh Tahir, Saira Saeed Khan, Sadaf Naeem, Adnan Iqbal, Nazish Jaffar, Sadia Sardar Sheikh, Nuzhat Sultana
Keywords: Antioxidant; Bitter gourd; Estrous cycle; Hormone; Metformin
DOI : 10.36721/PJPS.2026.39.3.REG.14365.1
Abstract: Background: This study investigated the therapeutic potential of aqueous fruit and seed extract of Momordica charantia L. (MC) as an alternative treatment for PCOS. Objectives: Evaluations included ovarian histopathology, fasting blood sugar, lipid profiles, antioxidant markers and hormone levels. Methods: Female Wistar rats induced with PCOS via a single 4.5?mg/kg dose of estradiol valerate were treated with MC extracts at 500 and 1000?mg/kg/day for 60 days. Results: The results showed that treatment with MC fruit and seed extract at the dose of 500 and 1000?mg/kg/day possesses potent anti-inflammatory and antioxidant activity in in-vitro models. MC fruit and seed extract showed no cytotoxicity in HeLa cell viability in the MTT assay and the highest antioxidant activity followed by DPPH compared with ascorbic acid (p?
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