Pakistan Journal of Pharmaceutical Sciences

Abstract: This review provides a comprehensive analysis of Amarogentin (AMA), a secoiridoid glycoside from the Gentianaceae family, highlighting its significant pharmacological effects. AMA demonstrates liver protection, anticancer, anti-inflammatory, antioxidant and antibacterial properties. Pharmacokinetic studies show rapid elimination and wide distribution of AMA in the body. Toxicity research indicates low toxicity to most cell types, although long-term and high-dose animal toxicity data are lacking. The therapeutic potential of AMA for liver fibrosis, cancer and diabetes is promising but further research is needed to explore its mechanisms, targets, toxicity and enhance oral bioavailability.