By: Khizra Zubair, Faiqa Zafar, Summaya Saif, Uzma Khaliq, Hamna Syed, Amna Sarfraz, Shah Rukh Sultan, Muhammad Imran Hussain, Tanzeela Nisar
Keywords: Hyperlipidemia; Herbal therapy; HDL; Lipid profile; LDL; Synergistic effect; Syzygium cumini; Triglycerides; Withania somnifera
DOI : 10.36721/PJPS.2026.39.7.200.1
Abstract: Background: Plants have long been used as natural remedies for various diseases. Withania somnifera and Syzygium cumini are known for their potential therapeutic effects, particularly in managing lipid disorders. Objectives: To evaluate the synergistic effects of Withania somnifera and Syzygium cumini on lipid profile in hyperlipidemic patients. Methods: This study included 60 patients, equally divided into four groups. Pre- and post-treatment assessments were conducted over 3 months. Group A (control) received Atorvastatin 10 mg HS; Group B received Withania somnifera (500 mg BD); Group C received Syzygium cumini (500 mg BD); and Group D received a combination of both (1000 mg QD). Data were analyzed using SPSS version 21 through paired sample t-test. Results: Withania somnifera showed significant improvement in low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL). Syzygium cumini significantly reduced cholesterol, triglycerides and systolic blood pressure. The combination therapy demonstrated the most pronounced effects, significantly reducing LDL, VLDL, cholesterol and triglycerides, while also improving high-density lipoproteins (HDL), without adverse effects. Conclusion: The combination of Withania somnifera and Syzygium cumini may be an effective and safe approach for managing hyperlipidaemia due to its beneficial impact on lipid profile.
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