By: Metin Deniz Karakoc, Ozlem Ozmen, Munevver Nazl?can Zengin, Osman Ciftci
Keywords: Docetaxel, oleuropein, oxidative stress, hepatotoxicity, nephrotoxicity.
DOI : 10.36721/PJPS.2025.38.5.REG.12955.1
Abstract: Docetaxel (Dtx) is a frequently used antineoplastic agent despite its dose-limiting toxic effects. Our objective was to assess the effects of oleuropein (Ole), a natural polyphenol, on Dtx-induced toxicity. Thirty-two male rats were randomly assigned to four groups for a four-week treatment: Control (sham), Dtx (5 mg/kg weekly, i.p.), Ole (30 mg/kg daily, p.o.) and Dtx+Ole. Biochemical and gene expression analyses were performed on liver, kidney and blood samples. Additionally, histological and immunohistochemical evaluations were conducted on the liver and kidneys. Ole reduced the Dtx-induced oxidative stress index in tissues. In contrast to Dtx, it decreased caspase-3 and Bax gene expressions while increasing Bcl-2 expression. Furthermore, Ole improved the ALT, AST, urea and creatinine levels, which were impaired by Dtx administration. It also reduced serum IL-6, IL-1? and TNF-? levels, which had been elevated due to Dtx. Histopathological and immunohistochemical examinations revealed that Ole administration mitigated Dtx-related damage in both tissues. These findings suggest that Ole might offer protection against Dtx-induced liver and kidney toxicity in rats.
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